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The effective dosage range of metoprolol tartrate tablets is 100-450 mg per day.

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During pregnancythis medication should be used only when clearly neededIt may harm an unborn babyDiscuss the risks and benefits with your doctor.

If clonidine and a beta blockersuch as metoprolol are coadministeredwithdraw the beta-blocker several days before the gradual withdrawal of clonidine because beta-blockers may exacerbate the rebound hypertension that can follow the withdrawal of clonidineIf replacing clonidine by betablocker therapydelay the introduction of beta-blockers for several days after clonidine administration has stoppedsee WARNINGS AND PRECAUTIONS

The relative beta 1selectivity of metoprolol has been confirmed by the following1In normal subjectsmetoprolol is unable to reverse the beta 2mediated vasodilating effects of epinephrineThis contrasts with the effect of nonselective beta-blockerswhich completely reverse the vasodilating effects of epinephrine2In asthmatic patientsmetoprolol reduces FEV 1 and FVC significantly less than a nonselective beta-blockerpropranololat equivalent beta 1receptor blocking doses.

Do not stop taking this medication without consulting your doctorSome conditions may become worse when you suddenly stop this drugSome people who have suddenly stopped taking similar drugs have had chest painheart attackand irregular heartbeatIf your doctor decides you should no longer use this drughe or she may direct you to gradually decrease your dose over 1 to 2 weeks.

TOPROL-XL tablets are used to treat heart failureIt is used in combination with other medicines to treat your condition.

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although small, this is the largest rdct comparing diltiazem versus metoprolol head to head randomization and blinding were well done.

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